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Research area · Data analytics

Mental Health Data Analytics

How to find, analyze and report real mental health data: the national datasets, the screening tools, the survey statistics in SAS, and the ethics of working with sensitive information.

Mental health data analytics means using real survey, health-record and death-certificate data to answer questions about who is struggling, who gets help and whether programs work. The United States has an unusually rich set of free public datasets, from the National Survey on Drug Use and Health to the Youth Risk Behavior Survey and NHANES, and each one comes with its own sampling design, weights and codebook. Learning statistics with these datasets gives students practice with messy, meaningful data while building skills that transfer to any field: cleaning, weighting, estimating prevalence, modeling risk and reporting results honestly. This page walks through the major datasets, the screening scales they use, the analysis workflow, the survey procedures in SAS (with R and Python notes), and the ethical rules that come with studying a sensitive and stigmatized topic.

13.1%People age 12+ with depression (PHQ-9 score of 10 or more), United States, Aug 2021–Aug 2023 (NHANES)National Center for Health Statistics, CDC, 2025 ↗
22.1% vs 7.4%Depression prevalence for people below the poverty level vs those at or above 400% of it, age 12+, Aug 2021–Aug 2023National Center for Health Statistics, CDC, 2025 ↗
40%U.S. high school students reporting persistent feelings of sadness or hopelessness, 2023 YRBS (down from 42% in 2021)CDC, 2024 ↗
65.7% vs 31.4%Persistent sadness or hopelessness among LGBQ+ vs heterosexual high school students, 2023 YRBSVerlenden et al., 2024 ↗
49,316Suicide deaths in the United States in 2023 (age-adjusted rate 14.1 per 100,000)National Center for Health Statistics, CDC, 2025 ↗
>60%College students meeting criteria for one or more mental health problems, 2020–2021 Healthy Minds StudyLipson et al., 2022 ↗
50.6%U.S. adults with any mental illness who received mental health treatment in the past year, 2022 NSDUHNational Institute of Mental Health, 2022 ↗
70,241Completed NSDUH interviews in 2024 (14,013 adolescents and 56,228 adults)SAMHSA, 2025 ↗
Explained

What the research shows

Open each part to read it. Every section lists the studies and federal sources it is based on.

Why mental health data matter

Good data turn vague worries into numbers that can guide action. Public health agencies use repeated national surveys for surveillance: tracking how common depression, anxiety, suicidal thoughts and substance use are, and whether those numbers are rising or falling. For example, NHANES data show depression among people age 12 and older rose from 8.2% in 2013–2014 to 13.1% in August 2021–August 2023.

Data also expose inequity. When results are broken out by income, race and ethnicity, sex, sexual orientation or gender identity, gaps appear that an overall average hides, such as depression being about three times as common below the poverty line as at the highest income level. Finally, data support program evaluation: a campus counseling expansion or a school connectedness program can be judged against baseline and comparison-group numbers rather than impressions.

Key points
  • Surveillance: how many people, which groups, and which direction the trend is going
  • Equity: disaggregated estimates reveal who carries the heaviest burden and who is left out of care
  • Program evaluation: before-and-after and comparison-group analyses show whether an intervention helped
  • Treatment gaps: comparing need with service use (for example, depression rising faster than help-seeking) points to where resources are missing
The major public datasets and how to get them

Most U.S. mental health datasets are free. Some are downloaded directly (YRBS, BRFSS, NHIS, NHANES, MEPS, Household Pulse). Others are distributed through an archive: NSDUH public-use files come from SAMHSA's data archive (SAMHDA) in SAS, SPSS, Stata, R and other formats, with a restricted version available only in secure research data centers. Death data (CDC WONDER, WISQARS) are queried online rather than downloaded as individual records. The Healthy Minds Study mainly returns data to participating campuses, so check its data-access rules before planning a class project.

Before analyzing anything, read three documents: the codebook (variable names and response codes), the methodology report (who was sampled and how), and the analytic guidelines (which weight and design variables to use). Mode changes matter too. For example, NSDUH moved to a mix of web and in-person interviews, and analysts caution against running trend tests straight across that change.

Key points
  • Download the codebook and user's guide alongside every data file
  • Note the population covered (household adults, high school students, college students, deaths)
  • Record which weight, stratum and cluster variables the documentation tells you to use
  • Check whether questions or modes changed between years before comparing trends
Screening scales: what the numbers mean

Most surveys do not diagnose anyone. They use short, validated screening questionnaires and treat a score above a cutoff as a sign of likely disorder. The PHQ-9 (depression) and GAD-7 (anxiety) are the most common. Their two-item versions, PHQ-2 and GAD-2, appear in fast surveys like the Household Pulse Survey. Distress scales like the Kessler K6 are used in NHIS, NSDUH and MEPS.

Cutoffs trade sensitivity against specificity. A large meta-analysis of individual participant data found that a PHQ-9 score of 10 or more had pooled sensitivity and specificity of about 0.85 each against semistructured interviews. A Cochrane review found that the GAD-7 at 10 or more was much better at ruling in generalized anxiety disorder (specificity 0.91) than at catching every case (sensitivity 0.64). Choosing a cutoff by maximizing accuracy in one small sample tends to overstate how well the scale works.

Key points
  • Report results as 'screened positive for' or 'symptoms of', not as a diagnosis
  • Use the cutoff your source report used, so your estimate can be compared with published figures
  • Handle 'refused' and 'don't know' codes (often 7 and 9) as missing before summing items
  • Be wary of 'optimal' cutoffs picked in small samples
The analysis workflow

A good project starts with a question narrow enough to answer with one dataset, such as 'Is depression screening prevalence higher among adolescents living below the poverty level?' Next, find the variables, then clean them: recode missing-value codes, build scale scores, create categories and define the subpopulation.

Only then do the statistics: weighted descriptive estimates with confidence intervals, then inferential tests and models, then clear charts. Finish with a written report that states the data source, years, design-based methods and limitations. Keeping every step in a script (a SAS program, R script or Python notebook) makes the work reproducible and easy to grade.

Key points
  • Write the question and the population first
  • Keep raw files untouched; do all recoding in code
  • Compare your weighted estimate to a published figure as a check
  • Document every decision (cutoffs, exclusions, missing-data handling)
Complex survey design and why SAS SURVEY procedures are needed

National surveys do not use simple random samples. They divide the country into strata, randomly select clusters (counties, schools, households) within strata, and oversample some groups. Each respondent then gets a weight: roughly, the number of people in the population they stand for, adjusted for unequal selection chances, nonresponse and coverage. The YRBS, for example, uses a three-stage cluster sample of county-based areas (PSUs), then schools, then classes (every student in a sampled class is asked), and CDC analyses use Taylor series linearization to account for that design.

Ignoring the design causes two different problems. Leaving out the weight biases the estimate itself, because oversampled groups count too much. Ignoring strata and clusters usually makes standard errors too small, so confidence intervals are too narrow and p-values too optimistic. SAS PROC SURVEYFREQ (weighted percentages and Rao-Scott chi-square tests), PROC SURVEYMEANS (means, totals and domain estimates) and PROC SURVEYLOGISTIC (logistic regression) take STRATA, CLUSTER and WEIGHT statements and fix both problems. In R the survey package does the same job (svydesign, svymean, svyglm), and in Python the samplics package is one option.

Key points
  • WEIGHT = the analysis weight named in the documentation (for example, WTMEC2YR for NHANES exam-based measures)
  • STRATA and CLUSTER = the design variables (for example, SDMVSTRA and SDMVPSU in NHANES)
  • Use DOMAIN (or a TABLES crossing) for subgroups instead of deleting other records with a WHERE statement
  • Some files (like Household Pulse) supply replicate weights instead of strata and clusters; use REPWEIGHTS with the method named in the documentation
Common statistical methods

Most mental health analyses of survey data rely on a few methods. Prevalence estimates with 95% confidence intervals answer 'how many?'. Design-adjusted chi-square tests answer 'is prevalence different across groups?'. Logistic regression produces odds ratios that compare the odds of an outcome between groups while holding other factors constant. For instance, a Household Pulse analysis found that energy-insecure adults had about 2.3 times the odds of depression symptoms after adjustment.

Trend analysis compares years or survey cycles, often with regression on time or joinpoint models, and must respect changes in methods. Missing data deserve explicit attention. Complete-case analysis is simple but can bias results if people who skip sensitive questions differ from those who answer. Multiple imputation is a common alternative, and at minimum you should report how many cases were dropped and why.

Key points
  • Prevalence + 95% CI (PROC SURVEYFREQ or SURVEYMEANS)
  • Rao-Scott chi-square for group differences (SURVEYFREQ CHISQ option)
  • Odds ratios from PROC SURVEYLOGISTIC; interpret an OR as a ratio of odds, not of percentages
  • Trends: model survey year and check documentation for breaks in comparability
  • Missing data: report amounts, compare responders and non-responders, consider multiple imputation
Data visualization good practice

Charts of mental health data should make comparisons easy and uncertainty visible. Use bar or dot charts with confidence-interval whiskers for group comparisons, and line charts for trends, marking any year where methods changed. Start bar axes at zero, label units (percent of students, rate per 100,000), and give the data source and years in a caption.

Avoid 3-D effects, dual axes and rainbow color scales, and do not rely on color alone to separate groups. When subgroup estimates are unstable because of small samples, show them as flagged or suppressed rather than drawing a confident-looking bar.

Key points
  • Show 95% confidence intervals on every estimate
  • Put the comparison you care about side by side
  • Caption with dataset, years, population and weighting
  • Use plain labels ('screened positive for depression') instead of variable names
Ethics, privacy and responsible reporting

Mental health information is among the most sensitive data people share. HIPAA governs health information held by providers and health plans, and its Privacy Rule allows two routes to de-identification: removing 18 kinds of identifiers (Safe Harbor) or having an expert certify that the risk of identification is very small. FERPA protects student education records, which matters for campus surveys and counseling data. Public-use survey files are already de-identified, but combining them with other data or reporting tiny subgroups can still reveal individuals. Studies using identifiable or restricted data need Institutional Review Board (IRB) review.

Responsible reporting goes beyond privacy. Suppress or flag small cells (CDC WONDER, for instance, withholds very small death counts), and avoid stigmatizing language: say 'people with depression', not 'the depressed'. For suicide data, follow safe-messaging guidance developed by suicide prevention groups with CDC, SAMHSA and NIMH: avoid describing methods or locations, don't call suicide 'epidemic' or 'skyrocketing' in sensational ways, and include help resources such as the 988 Suicide & Crisis Lifeline.

Key points
  • Use public-use files for teaching; restricted files require approved access
  • Never try to re-identify respondents or link files without approval
  • Suppress small cells and unstable estimates
  • Use person-first, non-stigmatizing language
  • Include 988 and prevention framing whenever you present suicide data
Equity analysis: disaggregating the data

Overall averages can hide large differences. Healthy Minds data showed mental health worsening in every racial and ethnic group of college students, with the largest increases among American Indian/Alaska Native students and the lowest treatment rates among students of color. YRBS 2023 was the first nationally representative survey to measure transgender identity among high school students, and it found that about 26% of transgender and questioning students had attempted suicide in the past year.

Disaggregation needs care. Subgroups can be small, so confidence intervals get wide. Pooling years or using domain analysis helps. Intersectional analyses, such as looking at sexual orientation and gender identity within racial and ethnic groups, can reveal patterns a single-factor analysis misses. Always report how groups were defined and remember that differences reflect social conditions like discrimination, poverty and access to care, not inherent traits of any group.

Key points
  • Break out results by race and ethnicity, sex, sexual orientation, gender identity, income and age
  • Pair prevalence gaps with treatment gaps
  • Pool survey years when subgroups are small
  • Frame disparities in terms of structural and social causes
Where the data are

Public mental health datasets

All of these are free for students. Survey datasets need their weights, strata and clusters to give correct national estimates.

DatasetWho runs itWhat it measuresMental health variablesDesign notes
National Survey on Drug Use and Health (NSDUH)
Civilian, noninstitutionalized people age 12+; 70,241 completed interviews in 2024 (about 40% web, 60% in person)
SAMHSA (HHS)Annual national survey of substance use, mental illness and treatmentPast-year major depressive episode (adolescent and adult modules), estimated any and serious mental illness, psychological distress, serious thoughts of suicide, suicide plans and attempts, mental health treatmentMultistage, state-based probability sample. Public-use files carry an analysis weight plus variance stratum and cluster (replicate) variables; use all three in SURVEY procedures. Mode changes since 2020 affect trend comparisons.
Youth Risk Behavior Survey (YRBS)
Students in grades 9–12 in public and private schools; 20,103 respondents in 2023
CDCSchool-based survey of health behaviors and experiences, run in odd-numbered yearsPersistent feelings of sadness or hopelessness, poor mental health, seriously considered suicide, made a suicide plan, attempted suicide, school connectedness, sexual identity and (from 2023) transgender identityThree-stage cluster sample (schools, classes, students). Data files include weight, stratum and PSU variables; CDC provides SAS input and format programs. CDC analyses use Taylor series linearization.
Behavioral Risk Factor Surveillance System (BRFSS)
More than 400,000 adult interviews a year in all 50 states, DC and some territories
CDC with state health departmentsState-based telephone survey of adult health behaviors and conditionsNumber of days mental health was not good in the past 30 days (frequent mental distress = 14 or more days), ever told you had a depressive disorder, optional modules such as sexual orientation and gender identityLandline and cell phone samples combined with raked weights; use the final weight (_LLCPWT), stratum (_STSTR) and PSU (_PSU) variables.
National Health Interview Survey (NHIS)
Civilian, noninstitutionalized U.S. household population; data files released annually (2025 is the latest year)
NCHS, CDCThe nation's largest and oldest household health surveyAnxiety (GAD-7) and depression (PHQ-8) symptom scales in the adult file, Kessler K6 distress, mental health care use and unmet needMultistage area probability sample; use the adult or child final weight with the pseudo-stratum and pseudo-PSU variables named in the documentation.
National Health and Nutrition Examination Survey (NHANES)
6,228 participants age 12+ in the depression analysis for August 2021–August 2023
NCHS, CDCInterviews plus physical exams and lab tests in mobile examination centersPHQ-9 items DPQ010–DPQ090 (0–3 each), impairment item DPQ100, counseling or therapy in the past 12 months15 masked variance strata and 30 PSUs in 2021–2023 (SDMVSTRA, SDMVPSU). The depression screener is asked during the exam-center visit, so NCHS uses the exam weight (WTMEC2YR).
Medical Expenditure Panel Survey (MEPS)
U.S. civilian, noninstitutionalized population (for example, 8,754 adults in one 2020 analysis)
AHRQ (HHS)Panel surveys of families, their medical providers and employers on health care use, spending and insuranceKessler K6 psychological distress and PHQ-2 depression screener in the self-administered questionnaire; mental health visits, prescriptions and spendingOverlapping panels with person weights and variance stratum and PSU variables for each file year.
Healthy Minds Study (HMS)
Undergraduate and graduate students; fielded at more than 675 colleges and universities since 2007
Healthy Minds Network (University-based research network; not a federal agency)Annual web survey of college student mental health, attitudes and help-seekingDepression and anxiety screeners, suicidal ideation, counseling and medication use, stigma and help-seeking attitudes, optional modules (substance use, eating, financial stress)Random samples of students within participating campuses; nonresponse weights adjust for known student characteristics (unobserved differences may remain). Data go to participating schools; outside researchers must request access.
Monitoring the Future (MTF)
More than 25,000 8th, 10th and 12th graders a year, plus a panel of about 20,000 adults ages 19 to 65 followed over time
University of Michigan, funded by the National Institute on Drug Abuse (NIH)Long-running study of drug use, attitudes and well-being among youth and adultsDepressive symptom items, self-esteem, loneliness, worries about societal problemsSchool-based multistage sample with weights; panel follow-ups allow cohort and longitudinal analyses.
National Vital Statistics System mortality data via CDC WONDER
A census of deaths (1968 to present), not a sample; for example, 49,316 suicides in 2023
NCHS, CDCAll U.S. death certificates, coded by underlying and multiple causes of deathSuicide (ICD-10 X60–X84, Y87.0), drug overdose by intent, deaths by age, sex, race and ethnicity, placeNo survey weights because it is a full count; rates are per 100,000 and often age-adjusted. WONDER restricts display of very small counts, and rates based on few deaths are flagged as unreliable.
Web-based Injury Statistics Query and Reporting System (WISQARS)
National death certificate data, emergency department injury estimates and NVDRS violent-death records
CDC Injury CenterInteractive tool for fatal and nonfatal injury data, violent deaths and injury costsSuicide and self-harm deaths and injuries, violent-death circumstances (via NVDRS), cost of injuryQuery tool that produces counts, rates, maps and charts; nonfatal estimates come from a sample of hospitals and carry wider uncertainty.
Household Pulse Survey (HPS)
U.S. adults contacted by email and text; very large samples (for example, 918,892 households July 2021–October 2022)
U.S. Census Bureau with partner agencies (mental health tables by NCHS)Rapid online survey launched in April 2020 to track how emerging issues affect households; relaunched in 2025 as part of the Household Trends and Outlook Pulse SurveyPHQ-2 depression and GAD-2 anxiety items (reference period changed from 7 days to 2 weeks in July 2021)Person weights with replicate weights for variance estimation; low response rates mean nonresponse bias is a concern.
Screening tools

Common measures

9 items
PHQ-9 (Patient Health Questionnaire-9)Depression symptoms over the past two weeks, one item for each DSM depression criterion
Each item 0–3, total 0–27. Common severity bands: 5 mild, 10 moderate, 15 moderately severe, 20 severe. A score of 10 or more is the standard screening cutoff (NCHS uses 10+ to define depression); at 10+, pooled sensitivity and specificity were about 0.85.
7 items
GAD-7 (Generalized Anxiety Disorder-7)Anxiety symptoms over the past two weeks
Each item 0–3, total 0–21. Bands of 5, 10 and 15 mark mild, moderate and severe symptoms. At the recommended cutoff of 10+, a Cochrane review found sensitivity 0.64 and specificity 0.91 for generalized anxiety disorder.
2 items
PHQ-2 and GAD-2Two-item short forms (first two items of the PHQ-9 and GAD-7) used in rapid surveys such as the Household Pulse Survey
Each item 0–3, total 0–6. A score of 3 or more is the usual cutoff for positive symptoms.
6 items
Kessler K6 / K10 psychological distress scalesNonspecific psychological distress (sadness, nervousness, restlessness, hopelessness, effort, worthlessness) in the past 30 days; K6 is a short form of the K10 and was built for NHIS
K6: each item 0–4, total 0–24; 13 or more defines serious psychological distress in NCHS reports. K10 has 10 items and a larger range.
20 items
PCL-5 (PTSD Checklist for DSM-5)Self-reported PTSD symptoms over the past month
Each item 0–4, total 0–80. A cutoff between 31 and 33 suggests probable PTSD; lower cutoffs catch more cases, higher ones reduce false positives.
10 items
AUDIT (Alcohol Use Disorders Identification Test)WHO screen for hazardous and harmful drinking and possible dependence
Total 0–40. WHO risk zones: 0–7 low risk, 8–15 hazardous use, 16–19 harmful use, 20+ possible dependence (needs further assessment).
From question to report

The analysis workflow

  1. Ask a focused question (who, what outcome, what comparison)
  2. Pick a dataset whose population and measures fit the question
  3. Read the codebook, methods report and analytic guidelines
  4. Clean: recode 7/9 and blanks to missing, build scale scores, define groups
  5. Identify the weight, strata and cluster (or replicate weight) variables
  6. Describe: weighted prevalence with 95% confidence intervals
  7. Test and model: Rao-Scott chi-square, survey logistic regression, trends
  8. Visualize with CIs, clear labels and suppressed unstable estimates
  9. Report methods, limitations and results in stigma-aware language

Worked example: Among U.S. residents age 12 and older in August 2021–August 2023, is screening positive for depression (PHQ-9 of 10 or more) more common in females than males, and does the difference hold after accounting for age and family income?

Data: NHANES August 2021–August 2023: Depression Screener file (DPQ_L) merged with Demographics file (DEMO_L) by SEQN

Variables
  • SEQN (respondent ID, merge key)
  • DPQ010–DPQ090 (PHQ-9 items, 0–3; 7 = refused, 9 = don't know)
  • RIAGENDR (gender: 1 male, 2 female)
  • RIDAGEYR (age in years)
  • INDFMPIR (ratio of family income to poverty)
  • WTMEC2YR (exam sample weight)
  • SDMVSTRA (masked variance pseudo-stratum)
  • SDMVPSU (masked variance pseudo-PSU)
/* Merge demographics and PHQ-9 items (files already imported, e.g., via PROC IMPORT or LIBNAME XPORT) */
data phq;
  merge demo_l(in=a) dpq_l;
  by seqn;
  if a;
  array d{9} dpq010 dpq020 dpq030 dpq040 dpq050 dpq060 dpq070 dpq080 dpq090;
  do i = 1 to 9;
    if d{i} in (7, 9) then d{i} = .;      /* refused / don't know -> missing */
  end;
  if n(of d{*}) = 9 then phq9 = sum(of d{*});
  if phq9 ne . then dep = (phq9 >= 10);
  if 0 <= indfmpir < 1 then pov = 1;         /* below poverty */
  else if 1 <= indfmpir < 2 then pov = 2;
  else if 2 <= indfmpir < 4 then pov = 3;
  else if indfmpir >= 4 then pov = 4;
  inanal = (ridageyr >= 12 and dep ne . and wtmec2yr > 0);
  drop i;
run;

/* Weighted prevalence by sex with 95% CIs and Rao-Scott chi-square */
proc surveyfreq data=phq;
  strata sdmvstra;
  cluster sdmvpsu;
  weight wtmec2yr;
  tables inanal*riagendr*dep / row cl chisq;
run;

/* Survey logistic regression, analysis restricted with DOMAIN */
proc surveylogistic data=phq;
  strata sdmvstra;
  cluster sdmvpsu;
  weight wtmec2yr;
  domain inanal;
  class riagendr(ref='1') pov(ref='4') / param=ref;
  model dep(event='1') = riagendr ridageyr pov;
run;

How to read the output. In the SURVEYFREQ output, look only at the INANAL=1 block. The 'Row Percent' for DEP=1 in each RIAGENDR row is the weighted percentage of males and females who screened positive, and the 95% confidence limits show the precision. Compare your figures to the NCHS published values for this cycle (16.0% for females, 10.1% for males); small differences can come from missing-data handling. The Rao-Scott chi-square p-value tests whether prevalence differs by sex once the design is accounted for. In SURVEYLOGISTIC, read the Odds Ratio Estimates table for the INANAL=1 domain: an odds ratio above 1 for RIAGENDR 2 vs 1 means females have higher odds of screening positive than males of the same age and income group, and a confidence interval that excludes 1 indicates a statistically significant difference. The POV odds ratios compare each income group with the highest (400%+ of poverty). Describe results as 'screened positive for depression', not 'diagnosed with depression'.

The SAS code is a teaching template written from the NHANES codebooks; run it on the downloaded files and check the log before reporting any number.

Peer-reviewed · 2021–2026

Journal articles

Studies from the last five years. Each link opens the article itself (DOI or PubMed Central), and open-access articles are free to read.

2026Psycho-OncologyOpen access
MEPS 2020 data showed similar rates of moderate or serious distress (22.4% vs 24.1%) and depression symptoms among adults with and without cancer, illustrating logistic models with interaction terms.
Sloan, K., Orionzi, D., & Muench, U. (2026). The relationship between diagnosed cancer and self-reported distress and depression: A cross-sectional study using the 2020 Medical Expenditure Panel Survey. Psycho-Oncology, 35(4), e70451. https://doi.org/10.1002/pon.70451
2025Cochrane Database of Systematic ReviewsOpen access
Across 48 studies, the GAD-7 at a cutoff of 10 or more had sensitivity 0.64 and specificity 0.91 for generalized anxiety disorder, so it rules in better than it rules out.
Aktürk, Z., Hapfelmeier, A., Fomenko, A., Dümmler, D., Eck, S., Olm, M., Gehrmann, J., von Schrottenberg, V., et al. (2025). Generalized Anxiety Disorder 7-item (GAD-7) and 2-item (GAD-2) scales for detecting anxiety disorders in adults. Cochrane Database of Systematic Reviews, 3, CD015455. https://doi.org/10.1002/14651858.CD015455
2025General PsychiatryOpen access
Weighted Healthy Minds data on 44,560 international students showed anxiety rising from 20.46% to 36.47% and depression from 20.44% to 35.37% between 2015–2016 and 2023–2024, while service use grew more slowly.
Zhai, Y., Xiong, Y., Almaawali, M., Tian, X., & Du, X. (2025). National trends of mental health and service utilisation among international students in the USA, 2015–2024. General Psychiatry, 38(5), e102124. https://doi.org/10.1136/gpsych-2025-102124
2025Journal of Mental HealthOpen access
Using PHQ-2 and GAD-2 data, transgender respondents had about twice the odds of depression and anxiety symptoms as cisgender respondents, with the highest odds among transgender bisexual people.
Ingle, C., Anderson, R., & Williams, A. (2025). Intersections of sexual orientation, gender identity, and race/ethnicity and odds of reporting depression and anxiety symptomology in the Household Pulse Survey. Journal of Mental Health, 35(2), 151–162. https://doi.org/10.1080/09638237.2025.2558508
2025JAMA Network OpenOpen access
Weighted Household Pulse analyses found that adults facing energy insecurity had higher adjusted odds of anxiety (OR 2.29) and depression (OR 2.31) symptoms.
Graff, M., & Aung, T. W. (2025). Energy insecurity and mental health symptoms in US adults. JAMA Network Open, 8(10), e2539479. https://doi.org/10.1001/jamanetworkopen.2025.39479
2025MMWR Surveillance SummariesOpen access
NVDRS data for 2022 showed suicide rates of 23.7 per 100,000 for males vs 6.1 for females, with the highest rate among American Indian or Alaska Native people (24.3).
Forsberg, K., Sheats, K. J., Blair, J. M., Nguyen, B. L., Amoakohene, E., Betz, C. J., & Lyons, B. H. (2025). Surveillance for violent deaths — National Violent Death Reporting System, 50 states, the District of Columbia, and Puerto Rico, 2022. MMWR Surveillance Summaries, 74(5), 1–42. https://doi.org/10.15585/mmwr.ss7405a1
2024JAMA Network OpenOpen access
Resampling showed that picking an 'optimal' PHQ-9 cutoff in small studies often misses the true population cutoff (8 or higher) and overstates sensitivity, a caution for any data-driven threshold.
Levis, B., Bhandari, P. M., Neupane, D., Fan, S., Sun, Y., He, C., Wu, Y., Krishnan, A., et al. (2024). Data-driven cutoff selection for the Patient Health Questionnaire-9 depression screening tool. JAMA Network Open, 7(11), e2429630. https://doi.org/10.1001/jamanetworkopen.2024.29630
2024MMWR SupplementsOpen access
In 2023, 39.7% of high school students had persistent sadness or hopelessness and 9.5% attempted suicide; school connectedness and parental monitoring were linked to lower risk.
Verlenden, J. V., Fodeman, A., Wilkins, N., Jones, S. E., Moore, S., Cornett, K., Sims, V., Saelee, R., & Brener, N. D. (2024). Mental health and suicide risk among high school students and protective factors — Youth Risk Behavior Survey, United States, 2023. MMWR Supplements, 73(4). https://doi.org/10.15585/mmwr.su7304a9
2024MMWR SupplementsOpen access
In the first nationally representative data on transgender students, 3.3% identified as transgender and about 26% of transgender and questioning students attempted suicide, compared with 5% of cisgender males.
Suarez, N. A., Trujillo, L., McKinnon, I. I., Mack, K. A., Lyons, B., Robin, L., Carman-McClanahan, M., Pampati, S., et al. (2024). Disparities in school connectedness, unstable housing, experiences of violence, mental health, and suicidal thoughts and behaviors among transgender and cisgender high school students — Youth Risk Behavior Survey, United States, 2023. MMWR Supplements, 73(4), 50–58. https://doi.org/10.15585/mmwr.su7304a6
2024American Journal of Public HealthOpen access
BRFSS data showed frequent mental distress among transgender adults rising from 18.9% in 2014 to 32.9% in 2021, widening the gap with cisgender adults.
Feir, D., & Mann, S. (2024). Temporal trends in mental health in the United States by gender identity, 2014–2021. American Journal of Public Health, 114(5), 523–526. https://doi.org/10.2105/AJPH.2024.307603
2024JAMA Network OpenOpen access
Monitoring the Future panel data showed that 19.1% of females in the most recent birth cohort had high depressive symptoms at age 18, higher than any earlier cohort, with elevated levels persisting into young adulthood.
Keyes, K. M., Kreski, N. T., & Patrick, M. E. (2024). Depressive symptoms in adolescence and young adulthood. JAMA Network Open, 7(8), e2427748. https://doi.org/10.1001/jamanetworkopen.2024.27748
2022American Journal of Preventive MedicineOpen access
Using NSDUH, past-year major depressive episode reached 9.2% of people age 12+ in 2020 (17.2% of ages 18–25), rising fastest among youth while help-seeking stayed flat.
Goodwin, R. D., Dierker, L. C., Wu, M., Galea, S., Hoven, C. W., & Weinberger, A. H. (2022). Trends in U.S. depression prevalence from 2015 to 2020: The widening treatment gap. American Journal of Preventive Medicine, 63(5), 726–733. https://doi.org/10.1016/j.amepre.2022.05.014
2022Journal of Affective DisordersOpen access
Among more than 350,000 students at 373 campuses, over 60% met criteria for at least one mental health problem in 2020–2021, and students of color had the lowest treatment rates.
Lipson, S. K., Zhou, S., Abelson, S., Heinze, J., Jirsa, M., Morigney, J., Patterson, A., Singh, M., et al. (2022). Trends in college student mental health and help-seeking by race/ethnicity: Findings from the national Healthy Minds Study, 2013–2021. Journal of Affective Disorders, 306, 138–147. https://doi.org/10.1016/j.jad.2022.03.038
2022MMWR SupplementsOpen access
A clear methods report showing how CDC builds a stratified, three-stage cluster sample, weights the data and reports response rates (18% overall), useful as a teaching model for survey design.
Rico, A., Brener, N. D., Thornton, J., Mpofu, J. J., Harris, W. A., Roberts, A. M., Kilmer, G., Chyen, D., et al. (2022). Overview and methodology of the Adolescent Behaviors and Experiences Survey — United States, January–June 2021. MMWR Supplements, 71(3), 1–7. https://doi.org/10.15585/mmwr.su7103a1
2022JAMA Network OpenOpen access
Using CDC cause-of-death data, the ratio of self-injury mortality to suicide rose from 1.39 in 1999–2000 to 2.12 in 2018–2019, suggesting that many self-harm deaths are not classified as suicide.
Rockett, I. R. H., Jia, H., Ali, B., Banerjee, A., Connery, H. S., Nolte, K. B., Miller, T., White, F. M. M., et al. (2022). Association of state social and environmental factors with rates of self-injury mortality and suicide in the United States. JAMA Network Open, 5(2), e2146591. https://doi.org/10.1001/jamanetworkopen.2021.46591
2021BMJOpen access
Pooling 100 studies with 44,503 participants, a PHQ-9 score of 10 or more gave sensitivity and specificity of about 0.85 against semistructured diagnostic interviews.
Negeri, Z. F., Levis, B., Sun, Y., He, C., Krishnan, A., Wu, Y., Bhandari, P. M., Neupane, D., et al. (2021). Accuracy of the Patient Health Questionnaire-9 for screening to detect major depression: Updated systematic review and individual participant data meta-analysis. BMJ, 375, n2183. https://doi.org/10.1136/bmj.n2183
Government sources

Federal data and reports

National Center for Health Statistics, CDC2025
Depression Prevalence in Adolescents and Adults: United States, August 2021–August 2023 (NCHS Data Brief No. 527)
NHANES-based depression estimates (PHQ-9 of 10 or more) by age, sex and income, trends since 2013–2014, and methods notes on exam weights and Taylor series variance.
CDC2024
2023 Youth Risk Behavior Survey Results
Highlights of 2021–2023 changes in high school students' mental health, including persistent sadness or hopelessness and suicidal thoughts.
SAMHSA2025
Key Substance Use and Mental Health Indicators in the United States: Results from the 2024 National Survey on Drug Use and Health
Annual national NSDUH report with mental health and substance use indicators, sample size and interview mode.
National Center for Health Statistics, CDC2025
Changes in Suicide Rates in the United States From 2022 to 2023 (NCHS Data Brief No. 541)
National Vital Statistics System suicide counts and age-adjusted rates by sex and age for 2022–2023.
National Institute of Mental Health (NIH)2022
Mental Illness (Statistics)
Summary of 2022 NSDUH estimates of any and serious mental illness among U.S. adults and the share receiving treatment.
National Center for Health Statistics, CDC (with U.S. Census Bureau)2024
Anxiety and Depression – Household Pulse Survey
Interactive national and state estimates of anxiety and depression symptoms from PHQ-2 and GAD-2 items, with notes on the change in reference period.
U.S. Census Bureau2025
Household Pulse Survey
Program page with data tools, tables and public-use files, and notes on the 2025 relaunch within the Household Trends and Outlook Pulse Survey.
U.S. Department of Health and Human Services, Office for Civil Rights2012
Guidance Regarding Methods for De-identification of Protected Health Information in Accordance with the HIPAA Privacy Rule
Explains the Safe Harbor (remove 18 identifier types) and Expert Determination methods of de-identifying health data.
National Center for Health Statistics, CDC2015
Serious Psychological Distress Among Adults: United States, 2009–2013 (NCHS Data Brief No. 203)
Defines serious psychological distress as a K6 score of 13 or more on the 0–24 scale and shows how NCHS reports it.
National Center for Health Statistics, CDC2023
NHANES August 2021–August 2023 Mental Health – Depression Screener (DPQ_L) Codebook
Variable names, wording and response codes (including 7 = refused and 9 = don't know) for the nine PHQ-9 items and the impairment question.
National Center for Health Statistics, CDC2024
NHANES Tutorials
Free modules on sample design, weighting, variance estimation and reliability, with sample SAS, SUDAAN, Stata and R code.
📖 Further reading

Recommended books

The Little SAS Book: A Primer (6th ed.)Lora D. Delwiche and Susan J. Slaughter · 2019 · SAS Institute

The standard beginner's guide to SAS programming: reading data, DATA step recoding and basic procedures.

Applied Survey Data Analysis (2nd ed.)Steven G. Heeringa, Brady T. West and Patricia A. Berglund · 2017 · CRC Press (Chapman & Hall)

Thorough, applied treatment of weights, strata, clusters, variance estimation and survey regression with national survey examples.

Complex Surveys: A Guide to Analysis Using RThomas Lumley · 2010 · Wiley

Written by the author of R's survey package; the go-to reference for design-based analysis in R.

R for Data Science (2nd ed.)Hadley Wickham, Mine Çetinkaya-Rundel and Garrett Grolemund · 2023 · O'Reilly Media

Free online and in print; teaches data import, cleaning, transformation and visualization in R.

Naked Statistics: Stripping the Dread from the DataCharles Wheelan · 2013 · W. W. Norton

An engaging, non-technical introduction to statistical thinking for students anxious about math.

Flexible Imputation of Missing Data (2nd ed.)Stef van Buuren · 2018 · CRC Press (Chapman & Hall)

Practical guide to multiple imputation and missing-data reasoning; free online version available.

Fundamentals of Data Visualization: A Primer on Making Informative and Compelling FiguresClaus O. Wilke · 2019 · O'Reilly Media

Clear principles for choosing chart types, showing uncertainty and using color well.

Tools and organizations

Resources

Vocabulary

Key terms

These terms are also in the flashcards and games.

Prevalence
The share of a population that has a condition or screens positive at a given time, usually shown as a percentage.
Surveillance
Ongoing, systematic collection and analysis of health data to track problems and guide action.
Survey weight
A number attached to each respondent showing how many people in the population they represent, adjusted for selection chances and nonresponse.
Stratum (strata)
Groups the population is divided into before sampling (for example, regions); sampling happens separately within each.
Cluster / PSU
A group of people sampled together, such as a county or school; the primary sampling unit is the first-stage cluster.
Complex survey design
Any sampling plan using stratification, clustering and unequal weights rather than simple random sampling.
Design effect
How much a complex design inflates variance compared with a simple random sample of the same size.
Taylor series linearization
A common method for estimating standard errors that accounts for strata, clusters and weights.
Replicate weights
Sets of alternative weights (for example, jackknife or BRR) used to estimate variance when design variables are not released.
Domain (subpopulation) analysis
Estimating results for a subgroup while keeping the full sample design, instead of deleting other records.
Confidence interval
A range of values that likely contains the true population value; a 95% CI reflects sampling uncertainty.
Rao-Scott chi-square
A version of the chi-square test adjusted for complex survey designs, produced by PROC SURVEYFREQ.
Odds ratio
The odds of an outcome in one group divided by the odds in another; above 1 means higher odds, below 1 lower odds.
Logistic regression
A model for a yes/no outcome that estimates odds ratios while adjusting for other variables.
Screening cutoff
The score on a questionnaire at or above which a person is classified as likely having a condition.
Sensitivity
The proportion of people who truly have a condition that a screening test correctly flags.
Specificity
The proportion of people without a condition that a screening test correctly clears.
Age-adjusted rate
A rate recalculated to a standard age distribution so groups or years with different age structures can be compared fairly.
Codebook
The document listing each variable's name, question wording and response codes.
De-identification
Removing or altering information so that data can no longer reasonably be linked to a specific person.
Small-cell suppression
Withholding counts or estimates based on very few people to protect privacy and avoid unreliable numbers.
Institutional Review Board (IRB)
A committee that reviews research with human participants to protect their rights and welfare.
Disaggregation
Breaking overall results into subgroups (race and ethnicity, sex, income, sexual orientation) to reveal differences.
Safe messaging
Guidelines for communicating about suicide in ways that reduce contagion risk and encourage help-seeking.
Multiple imputation
Filling in missing values several times with plausible predictions and combining results to reflect uncertainty.
All references (27)
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  2. Levis, B., Bhandari, P. M., Neupane, D., Fan, S., Sun, Y., He, C., Wu, Y., Krishnan, A., et al. (2024). Data-driven cutoff selection for the Patient Health Questionnaire-9 depression screening tool. JAMA Network Open, 7(11), e2429630. https://doi.org/10.1001/jamanetworkopen.2024.29630 https://pmc.ncbi.nlm.nih.gov/articles/PMC11584932/
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  27. National Center for Health Statistics, CDC. (2024). NHANES Tutorials. https://wwwn.cdc.gov/nchs/nhanes/tutorials/default.aspx